Standard Operating Procedures (SOPs)

The following SOPs are used in the AMP SCZ program to acquire measures/assessments for ~2500 participants over a 2 year period as described in the study design:

Data Flow
Team Leads: Sylvain Bouix, Justin Baker

Clinical Data Acquisition
This document describes the SOPs to acquire clinical data for each participant at every time point – starting at screening and continuing through all twelve study visits.
Team Leads: Alison Yung, Jean Addington

EEG Acquisition
This document describes the SOPs to acquire EEG for each participant at two time points – first at baseline and second at two months after study entry.
Team Leads: Daniel Mathalon, Gregory Light, Aysenil Belger, Spero Nicholas

MRI
Team Leads: Ofer Pasternak, Michael Harms

Cognitive Measures
This document describes the SOPs to acquire cognitive measures for each participant at five time points – first at baseline, then at two, six, 12 and 24 months after study entry.
Team Leads: Bill Stone, Kelly Allot

Fluid Biomarker
This document describes the SOPs to acquire fluid biomarkers (blood, saliva) for each participant at two time points – first at baseline and second at two months after study entry.
Team Leads: Dianna Perkins, Scott Clark

Actigraphy
This document describes the SOPs to acquire actigraphy data for each participant on a daily basis.
Team Leads: Justin Baker, John Torous

Ecological Momentary Assessment (EMA) and Passive Sensing (PS)
This document describes the SOPs used to acquire Digital Health data – both EMA and PS – for each participant on a daily basis.
Team Leads: Justin Baker, John Torous

Language Sample Acquisition
This document describes the SOPs to acquire language/free speech samples for each participant at two time points – first at baseline and second at two months after study entry.
Team Leads: Phillip Wolff, Cheryl Cocoran, Zarina R. Bilgrami, Guillermo Cecchi