What is Involved?

Participants in the study will meet with researchers once a month for the first year. In the second year, they will meet with researchers only twice.

Each meeting will include some of the activities listed below. For example, participants will complete interviews at each appointment; other measures such as physiological and clinical assessments will only occur at some of the appointments.

Researchers will go through the information with participants before they decide to be in the study. Some types of study activities include:

• Interviews: Participants will be asked questions about day-to-day life, activities, and things like mood and anxiety.
• Computer Activities: Participants will complete tasks that measure attention, memory, planning, and problem solving.
• Brain Activity Recording (EEG): Participants will have their brain activity measured using EEG, a non-invasive brain imaging technique. There will be two EEG sessions during the study.
• Brain Imaging Scan (MRI): Participants will complete two MRI scans during the study.
• Blood Sample: Participants will provide blood samples so that researchers can analyze potential markers of psychosis risk.
• Saliva Sample: Participants will provide saliva samples so that researchers can monitor levels of the stress hormone cortisol.
• Speech Sample: Participants will be asked to have a 20-minute audio-recorded conversation so that researchers can observe their speech patterns. Participants may agree to a video recording so that their facial characteristics and body language can be analyzed.
• Smartphone App (optional): Participants may agree to record their daily mood and behavior using a smartphone app. Participants will also be invited to wear a wristband (similar to a fitness tracking device) that will monitor their activity over a 12-month period.

Study Schedule